Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Validating deposition models in disease: what is needed?

W H Finlay1, C F Lange, W I Li

  • 1Aerosol Research Laboratory of Alberta, Department of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada. warren.finlay@ualberta.ca

Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine
|March 23, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High flow nasal cannula: Influence of gas type and flow rate on airway pressure and CO<sub>2</sub> clearance in adult nasal airway replicas.

Clinical biomechanics (Bristol, Avon)·2019
Same author

Topical contrast agents to improve soft-tissue contrast in the upper airway using cone beam CT: a pilot study.

Dento maxillo facial radiology·2013
Same author

An in vitro study on the deposition of micrometer-sized particles in the extrathoracic airways of adults during tidal oral breathing.

Annals of biomedical engineering·2013
Same author

Simulation of enhanced deposition due to magnetic field alignment of ellipsoidal particles in a lung bifurcation.

Journal of aerosol medicine and pulmonary drug delivery·2012
Same author

In vitro lung delivery of bacteriophages KS4-M and ΦKZ using dry powder inhalers for treatment of Burkholderia cepacia complex and Pseudomonas aeruginosa infections in cystic fibrosis.

Journal of applied microbiology·2010
Same author

Changes in collection efficiency in nylon net filter media through magnetic alignment of elongated aerosol particles.

Journal of occupational and environmental hygiene·2009
Same journal

ASTRA Satellite Symposium -"The Importance of Size".

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
Same journal

Aerosols for Medical Applications (GAeF Satellite Meeting).

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
Same journal

Mucus and cilia symposium.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
Same journal

Aerosol delivery systems.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
Same journal

Standardization.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
Same journal

Modeling.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
See all related articles

Experimental validation of theoretical aerosol deposition models requires comprehensive in vivo data. Measuring parameters like breathing flow rates and aerosol properties is crucial for accurate model development and confidence in assumptions.

Area of Science:

  • Aerosol science
  • Computational modeling
  • Respiratory system physiology

Background:

  • Theoretical deposition models simplify complex respiratory tract dynamics for computational efficiency.
  • In vivo validation is essential to confirm the assumptions made in these theoretical models.
  • Current experimental methods often lack the comprehensive data needed for robust model validation.

Purpose of the Study:

  • To highlight the critical parameters required for in vivo validation of aerosol deposition models.
  • To emphasize the need for detailed experimental measurements to improve model accuracy.
  • To discuss the importance of extrathoracic region data for deposition modeling.

Main Methods:

  • Review of requirements for in vivo deposition experiments.

Related Experiment Videos

  • Discussion of essential parameters for model input, including breathing flow, aerosol properties, and lung geometry.
  • Emphasis on the need for mouth-throat filtering data.

    • Main Results:

    • Identification of key parameters for in vivo validation: time-dependent breathing flow, aerosol characteristics (size, mass, hygroscopicity), lung anatomy, and extrathoracic filtering.
    • Acknowledgement of current experimental limitations in measuring all necessary parameters.
    • Demonstration of data's importance through examples.

    Conclusions:

    • Comprehensive in vivo data collection is vital for advancing aerosol deposition model development.
    • Future experiments should aim to measure a wider range of parameters to enhance model reliability.
    • Improved experimental data will increase confidence in computational models of aerosol deposition.