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Perception of hunger to insulin-induced hypoglycemia in anorexia nervosa
1College of Medical Technology, Kyoto University, 53 Kawaha-racho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Objective:
We studied the effect of insulin-induced hypoglycemia on changes of hunger ratings in anorectic patients before and after cognitive-behavioral therapy.
Method:
The subjects were 17 females with restricting anorexia nervosa at low body weight (AN-R), 6 anorectic patients whose weight was restored after cognitive-behavioral therapy (AN-T), and 11 age-matched female controls. All subjects gave hunger ratings by linear visual analog technique before and after insulin or saline injection.
Results:
Hunger ratings increased significantly 45 min after insulin injection in control females. However, ratings paradoxically decreased after insulin injection in AN-R females. They increased slightly after insulin injection in AN-T females, but the difference was not statistically significant. One-factor analysis of variance for the peak values of hunger ratings was significant. These values in control females were significantly higher than those in AN-R and AN-T females.
Discussion:
These results suggest that perception of hunger to insulin-induced hypoglycemia in AN patients is disturbed.