Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metabolic alkalosis.

A Khanna1, N A Kurtzman

  • 1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Respiratory Care
|March 23, 2001
PubMed
Summary
This summary is machine-generated.

Metabolic alkalosis results from gaining bicarbonate or losing acid. The kidneys maintain balance through bicarbonate reabsorption and generation, influenced by factors like chloride and aldosterone. Treatment involves addressing causes and sometimes specific therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First report of full colon transplantation as part of a visceral allograft.

Techniques in coloproctology·2025
Same author

Work-related musculoskeletal pain and discomfort in laparoscopic surgeons: an international multispecialty survey.

Annals of the Royal College of Surgeons of England·2023
Same author

A systematic review of point-of-care abdominal ultrasound scans performed by general surgeons in paediatric patients.

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·2023
Same author

Identifying the optimal developmental age of human pluripotent stem cell-derived midbrain dopaminergic progenitors for transplantation in a rodent model of Parkinson's disease.

Experimental neurology·2022
Same author

Effectiveness of two tobacco cessation methods among TB patients.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2021
Same author

Risk of childhood TB from non-adherence to isoniazid chemoprophylaxis.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2021
Same journal

Response to the Letter to the Editor Regarding "Comparative Evaluation of Risk Scores for Predicting Postoperative Pulmonary Complications".

Respiratory care·2026
Same journal

Respiratory Muscle Dysfunction in Stable COPD: A Multimodal Assessment of Diaphragmatic and Cough-Related Impairment.

Respiratory care·2026
Same journal

Flow Asynchronies During Pressure Support Ventilation in Children: A Bench Model Study.

Respiratory care·2026
Same journal

Inspiratory Effort Assessment Using the Occlusion Pressure-Derived Tension-Time Index.

Respiratory care·2026
Same journal

Clinical Usage of High-Flow Nasal Cannula Across Disease Categories and Care Settings: A Nationwide Cohort Study in Japan.

Respiratory care·2026
Same journal

Efficacy of Mechanical Insufflation-Exsufflation Devices as Analyzed in Lung Models: Systematic Review and Network Meta-Analysis of Peak Expiratory Flow Data.

Respiratory care·2026
See all related articles

Area of Science:

  • Nephrology
  • Physiology
  • Acid-Base Balance

Background:

  • Metabolic alkalosis is a disorder of acid-base balance.
  • It involves an excess of bicarbonate or a deficit of nonvolatile acid in extracellular fluid.
  • The kidney plays a crucial role in maintaining acid-base homeostasis through bicarbonate reclamation and generation.

Purpose of the Study:

  • To detail the pathophysiological mechanisms of metabolic alkalosis.
  • To identify factors influencing bicarbonate reabsorption and generation.
  • To outline clinical conditions and treatment strategies for metabolic alkalosis.

Main Methods:

  • Review of renal mechanisms for bicarbonate handling (reclamation and generation).
  • Analysis of factors affecting these mechanisms, including hormonal and electrolyte influences.

Related Experiment Videos

  • Compilation of clinical states and therapeutic interventions for metabolic alkalosis.

    • Main Results:

    • Bicarbonate reclamation occurs in the proximal tubule via Na(+)-H(+) antiporter and H(+)-ATPase.
    • Bicarbonate generation in the distal nephron is influenced by Na(+) delivery, aldosterone, and CO2 levels.
    • Factors like volume contraction, hypokalemia, and hypochloremia can perpetuate metabolic alkalosis.

    Conclusions:

    • Metabolic alkalosis arises from acid loss (GI or renal) or base gain.
    • Understanding renal handling of bicarbonate is key to managing this condition.
    • Treatment focuses on reversing underlying causes and may involve specific therapies for severe cases.