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Updated: Aug 3, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
11:55

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Treatment of severe thrombocytopenia in alloimmunized, transfusion-refractory patients

D L Ornstein1, K L Mortara, M B Smith

  • 1Bone Marrow Transplantation Service and Hematology/Oncology Flight, Wilford Hall U.S. Air Force Medical Center/59 MDW, Lackland Air Force Base, San Antonio, TX 78236, USA.

Military Medicine
|March 27, 2001
PubMed

A significant proportion of patients with hematologic malignancies who are exposed to multiple transfusions will develop alloantibodies to platelet human leukocyte antigens (HLA), resulting in poor responses to subsequent platelet transfusions. Transfusion of HLA-identical platelets is an effective method of platelet support in these patients, but perfectly HLA-matched platelets are often not available. In this paper, we review the recent literature on platelet transfusion support in alloimmunized individuals and illustrate alternative management strategies with cases from our own practice.

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