Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lithium administration antagonizes cholinergic behavioral effects in rodents.

D S Janowsky, A A Abrams, G P Groom

    Psychopharmacology
    |May 25, 1979
    PubMed
    Summary

    Physostigmine, a cholinesterase inhibitor, reduces methylphenidate-induced behaviors in rodents. Lithium chloride counteracts this effect, suggesting it may inhibit central cholinergic activity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Monoamines and ovarian hormone-linked sexual and emotional changes: A review.

    Archives of sexual behavior·2013
    Same author

    Successful treatment of hydramnios with ammonium chloride; a preliminary report.

    American journal of obstetrics and gynecology·2010
    Same author

    Innovative programs for the decade of the brain.

    Journal of child and adolescent psychopharmacology·2009
    Same author

    Introversion and extroversion: implications for depression and suicidality.

    Current psychiatry reports·2001
    Same author

    Major depressive disorder: longitudinal symptomatic structure, relapse and recovery.

    Acta psychiatrica Scandinavica·2001
    Same author

    Core heritable personality characteristics and relapse in alcoholics.

    Alcoholism, clinical and experimental research·2001

    Area of Science:

    • Neuropharmacology
    • Behavioral Neuroscience
    • Psychopharmacology

    Background:

    • Methylphenidate is a stimulant known to induce stereotyped behaviors.
    • Physostigmine, a centrally acting cholinesterase inhibitor, has been shown to antagonize such behaviors.
    • Understanding the neurochemical underpinnings of stimulant-induced behaviors is crucial for developing therapeutic strategies.

    Purpose of the Study:

    • To investigate the interaction between physostigmine and lithium chloride in the context of methylphenidate-induced behaviors.
    • To explore the potential role of central cholinergic activity in mediating these drug interactions.
    • To examine the implications for the adrenergic-cholinergic balance hypothesis in affective disorders.

    Main Methods:

    • Administration of physostigmine and methylphenidate to mice and rats.

    Related Experiment Videos

  • Concurrent administration of lithium chloride with physostigmine and methylphenidate.
  • Observation and quantification of stereotyped gnawing behavior.

    • Main Results:

    • Physostigmine effectively antagonized methylphenidate-induced stereotyped gnawing behavior.
    • The co-administration of lithium chloride significantly attenuated the effects of physostigmine.
    • This attenuation suggests that lithium chloride may interfere with central cholinergic pathways.

    Conclusions:

    • Lithium chloride appears to antagonize central cholinergic activity, as evidenced by its effect on physostigmine's action.
    • The findings support the involvement of cholinergic systems in methylphenidate-induced behaviors.
    • This research offers potential insights into the adrenergic-cholinergic balance theory of mood regulation.