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[Studies of tumor necrosis factor-alpha and red cell immunity state in multiple myeloma]
1Department of Hematology, Chaoyang Hospital, Capital Medical University, Beijing 100020.
Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi
|March 27, 2001
Abstract
Objective:
To explore factors in the pathogenesis of multiple myeloma (MM).
Methods:
The plasma level of tumor necrosis factor-alpha (TNF alpha) was measured by immunoassay in 21 MM patients, and red cell immunologic function was assayed in 16 patients.
Results:
There was no difference in TNF alpha levels among patients with either fulminant MM or stable MM and normal controls. The rosette formation rate of red cell C3 bR and red cell immune complex was significantly lower in MM patients than in the controls.
Conclusion:
MM patients might have impaired monocyte-phagocyte system and red cell immune function.