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[Clinical analysis of 164 cases Coombs test positive autoimmune hemolytic anemia]
1Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020.
Objective:
To analyze the clinical features and treatment outcomes of autoimmune hemolytic anemia (AIHA).
Methods:
Coombs test positive AIHA patients were retrospectively analyzed.
Results:
Patients with AIHA were predominantly female, secondary AIHA accounted for 49% of the total cases, mainly associated with connective tissue diseases. In most cases of AIHA, the anti-red cell antibodies were IgG plus C3, while patients with IgG plus IgM had more severe clinical manifestations. The response rate of adrenocortical hormones and cyclosporin A (CsA) was 90.9%.
Conclusion:
Adrenocorticosteroids is still the first choice of therapy for AIHA, CsA can improve the response rate.