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[TNF-alpha production and antitumor effect of rhIL-2-activated bone marrow cells]
Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi
|March 27, 2001
Abstract
Objective:
To explore the mechanism of the cytotoxic effects of bone marrow cells activated with recombinant human interleukin-2(rhIL-2).
Methods:
The cytotoxicity of rhIL-2-activated bone marrow (ABM) and the TNF-alpha level in the supernant of ABM culture were measured after activated for 24 and 48 hours.
Results:
The cytotoxic activity against HL-60 cells and the level of TNF-alpha were significantly increased in ABM as compared with that in non-ABM(P < 0.01). Meanwhile, there was a significantly positive relationship between the TNF-alpha levels in supernant and cytotoxicities of ABM.
Conclusion:
TNF-alpha produced by rhIL-2 activated bone marrow cells involved in the antitumor effect of ABM.