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[Expression and prognostic relation of cathepsin D in non-small cell lung cancer tissues and lymph nodes]
1Cancer Center, Xin Qiao Hospital, Third Medical University of PLA, Chong Qing 400037.
Objective:
To study the expression and prognostic significance of cathepsin D(CD) in the patients with lung cancer.
Method:
A rapid immunohistochemical method (streptavidin-peroxidase conjugated method, SP) was used to detect CD expression of the NSCLC patients in 64 cases lung cancer tissues and paired lymph nodes samples.
Result:
The results showed positive expression rate of CD was 66% (42/64) in the lung cancer tissues, of which squamous cell cancer was 57% (17/30), adenocarcinoma was 74%(25/34). In the metastatic lymph nodes, the expression of CD was 57%(20/35). Expression of CD was higher in the patients with stage III-IV than in that with stage I-II (P < 0.05), of which was markedly higher in adenocarcinoma with lymph nodes metastasis than in which lymph nodes negative.
Conclusion:
Higher expression of CD is significantly related to the stage of the disease and lymph node metastasis in the adenocarcinoma. The expression of CD may be a good marker of prognosis in NSCLC.