Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemoglobin solution: a potential oxygen transporting plasma volume expander.

H R Kaplan, V S Murthy

    Federation Proceedings
    |May 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Emerging pattern of clozapine prescription in India: a cause for concern?

    Acta psychiatrica Scandinavica·2014
    Same author

    Small ureterocele-like Gartner's duct cyst associated with ipsilateral renal aplasia: a case report.

    Australasian radiology·2001
    Same author

    Primary liposarcoma of the mediastinum.

    Journal of the Indian Medical Association·2000
    Same author

    In transition. Empowering your menopausal patients.

    Advance for nurse practitioners·1997
    Same author

    Exceeding the Healthy People 2000 goal for influenza vaccination through a collaborative effort at eight primary care clinics.

    Wisconsin medical journal·1996
    Same author

    Mental retardation, short stature and brittle hair (BIDS syndrome; hair brain syndrome).

    Indian journal of pediatrics·1996
    Same journal

    ASBESTOS FIBERS MEDIATE THE UPTAKE OF DNA INTO PRIMATE CELLS IN CULTURE.

    Federation proceedings·2018
    Same journal

    Chemical protection of mammalian tissues.

    Federation proceedings·2014
    Same journal

    Dietary requirements for fertility and lactation; dried yeasts as sources of proteins and vitamin B complex for growth, reproduction and lactation.

    Federation proceedings·2010
    Same journal

    On the mode of action of chlorinating compounds.

    Federation proceedings·2010
    Same journal

    d-Amino acid oxidase of Proteus morganii.

    Federation proceedings·2010
    Same journal

    Studies on thymus nucleohistone.

    Federation proceedings·2010
    See all related articles

    A novel hemoglobin solution (WXb8326) effectively expanded plasma volume and transported oxygen in dogs. It enabled survival even at critically low hematocrit levels, outperforming other expanders.

    Area of Science:

    • Biomedical Engineering
    • Hematology
    • Critical Care Medicine

    Background:

    • Plasma volume expanders are crucial in managing blood loss and shock.
    • Existing expanders have limitations in oxygen-carrying capacity.
    • Human hemoglobin solutions offer potential for oxygen transport.

    Purpose of the Study:

    • To evaluate a 6% stroma-free human hemoglobin solution (WXb8326) as a plasma volume expander.
    • To assess its oxygen transport capabilities in a canine model.
    • To compare its efficacy against dextran-70 and 5% albumin.

    Main Methods:

    • Anesthetized spontaneously breathing dogs underwent serial phlebotomies and colloid replacement.
    • Hematocrit levels were reduced to critical levels (≤5%) and survival was monitored.

    Related Experiment Videos

  • Oxygen transport characteristics during isovolumic hemodilution were studied.
  • Oxygen content of erythrocytic (EHb) and extraerythrocytic hemoglobin (EEHb) was analyzed.

    • Main Results:

    • WXb8326 demonstrated superior survival rates at hematocrit levels ≤5% compared to dextran-70 and albumin.
    • All dogs survived acute reductions to 5-10% hematocrit, but subacute survival varied.
    • WXb8326 effectively oxygenated EEHb without interfering with EHb oxygen saturation.
    • EEHb contributed oxygen to tissues during high oxygen demand.

    Conclusions:

    • WXb8326 is a promising candidate for a plasma volume expander with oxygen transport function.
    • Its ability to maintain oxygen delivery at critically low hematocrit is significant.
    • Further research into its clinical application is warranted.