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Metabolism of fluorine-containing drugs
B K Park1, N R Kitteringham, P M O'Neill
1Department of Pharmacology and Therapeutics, New Medical Building, University of Liverpool, Liverpool, United Kingdom. bkpark@liverpool.ac.uk
Annual Review of Pharmacology and Toxicology
|March 27, 2001
Abstract:
This article reviews current knowledge of the metabolism of drugs that contain fluorine. The strategic value of fluorine substitution in drug design is discussed in terms of chemical structure and basic concepts in drug metabolism and drug toxicity.