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Penicillin resistance in Streptococcus pneumoniae in Isparta
1Department of Chest Disease, Süleyman Demirel University, School of Medicine, Turkey.
Respirology (Carlton, Vic.)
|March 27, 2001
Summary
Procaine penicillin remains effective for treating pneumococcal pneumonia, as most Streptococcus pneumoniae strains isolated showed penicillin sensitivity or moderate resistance. No high-level resistance or treatment failures were observed in this study.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Penicillin-resistant Streptococcus pneumoniae (pneumococci) emerged in the late 1960s and 1970s, posing a significant therapeutic challenge.
- The increasing prevalence of penicillin resistance in S. pneumoniae necessitates ongoing evaluation of treatment efficacy.
Purpose of the Study:
- To assess the penicillin resistance levels of S. pneumoniae strains isolated in a laboratory setting.
- To investigate the effectiveness of procaine penicillin treatment against these isolated strains.
Main Methods:
- Sensitivity testing utilized the disc diffusion method with oxacillin discs.
- Minimal inhibitory concentration (MIC) values for penicillin were determined using E-tests.
- Patients received intramuscular procaine penicillin (2 x 800,000 IU every 12 hours for 10 days).
Main Results:
- Out of 37 S. pneumoniae isolates from adult pneumonia patients, 28 (75.7%) were penicillin-sensitive and 9 (24.3%) were moderately resistant (MIC 0.12-1.00 microg/mL).
- No high-level penicillin-resistant strains of S. pneumoniae were detected.
- All patients treated with procaine penicillin experienced successful therapeutic outcomes without failure.
Conclusions:
- Procaine penicillin demonstrated efficacy in treating pneumococcal pneumonia in this study.
- These findings suggest that procaine penicillin can still be a viable option for empirical treatment of pneumococcal pneumonia.