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Updated: Aug 11, 2026

Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures
Published on: January 6, 2010
Flow and Oxygen Transfer Characteristics of an Intravenous Membrane Oxygenator: A Computational Study
Abstract:
Spectral element computational simulations of the conservation of mass, momentum and species equations are performed to investigate the flow and oxygen transfer characteristics of an Intravenous Membrane Oxygenator (IMO). The simulations consider a three-dimensional IMO computational model consisting of equally-spaced fibers, an elastic balloon with non-permeable walls positioned longitudinally within the vena cava, and a Newtonian and time-dependent incompressible flow. Flow characteristics and oxygen transfer parameters are determined for operating conditions of a stationary and a pulsating balloon. For the stationary balloon configuration the flow is two-dimensional, parallel, laminar and without secondary flows for the Reynolds number range of 5.7-455.2. Evaluations of the oxygen transfer characteristics for the stationary balloon indicate that the main transport mechanisms are diffusion and convection in the crosswise and streamwise directions, respectively. Additionally, evaluations of oxygen transfer rates and Sherwood numbers in this Reynolds number range indicate that the oxygen transfer rate reaches an asymptotic limit at relatively moderate Reynolds numbers. For the pulsating balloon, flow characteristic results demonstrate the existence of a strong secondary flow around the fiber, and between the balloon and the fiber. This secondary flow induces oscillatory crosswise and streamwise velocities and a seemingly random spanwise flow which enhances the flow mixing as well as the transport of oxygen from the fiber surface to the bulk flow.
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