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Updated: Oct 9, 2026

Recombineering Homologous Recombination Constructs in Drosophila
Published on: July 13, 2013
Mini- and microsatellite expansions: the recombination connection
1Unité de Génétique Moléculaire des Levures, URA 2171 CNRS, Paris, France. gfrichar@pasteur.fr
Abstract:
It is widely accepted that the large trinucleotide repeat expansions observed in many neurological diseases occur during replication. However, genetic recombination has emerged as a major source of instability for tandem repeats, including minisatellites, and recent studies raise the possibility that it may also be responsible for trinucleotide repeat expansions. We will review data connecting tandem repeat rearrangements and recombination in humans and in eukaryotic model organisms, and discuss the possible role of recombination in trinucleotide repeat expansions in human neurological disorders.
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