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10:27

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Blockade of the CD40 pathway fails to prevent CD8 T cell-mediated intestinal allograft rejection

L Meng1, Z Guo, O Kim

  • 1Department of Surgery, The University of Chicago, Chicago, Illinois, USA.

Transplantation Proceedings
|March 27, 2001
PubMed
Abstract

No abstract available in PubMed .

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...