Differentiation of endoderm derivatives, pancreas and intestine, from rhesus embryonic stem cells

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L Jacobson1, B Kahan, A Djamali

  • 1Department of Surgery, University of Wisconsin-Madison School of Medicine, William S. Middleton VA Hospital, Madison, Wisconsin, USA.

Transplantation Proceedings
|March 27, 2001
PubMed
Abstract

No abstract available in PubMed .

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Renewal of Intestinal Stem Cells01:23

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

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