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HELLP syndrome and factor V Leiden.

M Bozzo1, G Carpani, L Leo

  • 1Department of Obstetrics and Gynaecology, San Paolo Biomedical Sciences Institute, University of Milan, Milan, Italy.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|March 27, 2001
PubMed
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This study found no Factor V Leiden mutation in women with HELLP syndrome, challenging previous reports. The findings suggest the association may be linked to preeclampsia rather than HELLP syndrome directly.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Thrombophilia

Background:

  • Thrombophilia is linked to obstetric complications, potentially due to placental issues.
  • Factor V Leiden is a common thrombophilic mutation.
  • Previous research suggested a high prevalence of Factor V Leiden in HELLP syndrome.

Purpose of the Study:

  • To investigate the prevalence of Factor V Leiden in women diagnosed with HELLP syndrome.
  • To examine coagulation parameters in women with HELLP syndrome.

Main Methods:

  • Studied 18 women with HELLP syndrome.
  • Assessed coagulation parameters, including Factor V Leiden mutation (G1691A), APC resistance, and other thrombophilic markers.
  • Testing was performed at diagnosis or post-delivery.

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Main Results:

  • All tested coagulation parameters were normal in the studied women.
  • Factor V Leiden mutation (G1691A) was not detected in any of the 18 women.
  • No APC resistance was observed.

Conclusions:

  • The study did not find an association between Factor V Leiden and HELLP syndrome in this cohort.
  • The previously reported link between Factor V Leiden and HELLP may be related to the association with preeclampsia.
  • Further research is needed to clarify the role of thrombophilia in HELLP syndrome.