Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Centrosomes: Central no more?

J W Raff1

  • 1Wellcome/CRC Institute, Tennis Court Road, Cambridge, CB2 1QR, UK. j.raff@welc.cam.ac.uk

Current Biology : CB
|March 27, 2001
PubMed
Summary
This summary is machine-generated.

Centrosomes, crucial for cell division, are not essential for fly development. Flies can develop normally even without functional mitotic centrosomes, challenging previous biological assumptions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tissue-specific antigens secreted by suspension-cultured callus cells of Prunus avium L.

Planta·2013
Same author

Style antigens of Prunus avium L.

Planta·2013
Same author

The centrosomal protein CP190 regulates myosin function during early Drosophila development.

Current biology : CB·2005
Same author

The Drosophila centrosome-associated protein CP190 is essential for viability but not for cell division.

Journal of cell science·2004
Same author

Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour.

Nature cell biology·2001
Same author

The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.

Proceedings of the National Academy of Sciences of the United States of America·2000
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Genetics

Background:

  • Centrosomes are key microtubule-organizing centers traditionally considered essential for animal cell division.
  • Recent studies challenge the absolute requirement of centrosomes in certain developmental contexts.

Purpose of the Study:

  • To investigate the necessity of functional mitotic centrosomes for zygotic development in Drosophila melanogaster.
  • To determine if centrosomes are universally required for cell division in animals.

Main Methods:

  • Utilizing genetic mutations to disrupt centrosome function in fruit flies.
  • Observing and analyzing the developmental progression and morphology of flies lacking functional centrosomes.
  • Employing microscopy techniques to assess cellular division and organization.

Related Experiment Videos

Main Results:

  • Zygotic development of morphologically normal flies was observed despite the absence of properly functioning mitotic centrosomes.
  • Cell division and embryonic development proceeded successfully without canonical centrosome function.

Conclusions:

  • Functional mitotic centrosomes are not strictly required for the zygotic development of a morphologically normal fly.
  • This challenges the long-held view of centrosomes as indispensable for animal cell division and development.