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Conditioning rhinitis in allergic humans.

J E Barrett1, M G King, G Pang

  • 1Department of Psychology, University of Newcastle, NSW, 2308, Australia. judy.barrett@dsto.defence.gov.au

Annals of the New York Academy of Sciences
|March 28, 2001
PubMed
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Classical conditioning can trigger histamine release and nasal airflow changes in allergic rhinitis patients. However, these conditioned responses can be extinguished and strengthen with repeated allergen exposure.

Area of Science:

  • Psychoneuroimmunology
  • Allergy Research

Background:

  • Seasonal allergic rhinitis involves histamine release and nasal airflow changes.
  • Classical conditioning paradigms can influence physiological responses in allergic conditions.

Purpose of the Study:

  • To investigate conditioned histamine release and nasal airflow changes using Pavlovian conditioning in allergic rhinitis.
  • To examine the effect of single versus multiple training trials on these conditioned responses.

Main Methods:

  • A classical Pavlovian paradigm paired an olfactory cue with an allergen challenge.
  • Histamine release, nasal airflow, and subjective symptoms were measured.
  • Extinction and dose-response effects of training trials were assessed.

Main Results:

Related Experiment Videos

  • A single training trial produced conditioned histamine release and nasal airflow decrease, but not subjective symptoms.
  • Conditioned responses showed evidence of extinction by the second test trial.
  • Three training trials resulted in greater histamine release and airflow decrease compared to a single trial.

Conclusions:

  • Classical conditioning can elicit measurable physiological responses in seasonal allergic rhinitis.
  • Conditioned responses are subject to extinction and can be potentiated by increased training.
  • This suggests a potential role for psychological factors in modulating allergic reactions.