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[Human obesity and point mutations of leptin and leptin receptor]
H Nishimura1, Y Ogawa, K Nakao
1Department of Diabetes and Endocrinology, Osakafu Saiseikai Hospital.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 28, 2001
Abstract:
Obesity-related genes were isolated and identified in these several years. Development of transgenic mice has clarified the molecular mechanisms of obesity. There have been reported point mutations of the genes correspond to leptin(ob-gene) and leptin receptor(db-gene). Thereby leptin is considered to be one of the most important regulators of energy metabolism also in human.