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Synthesis and biological activity of the structural analogues of (-)-cabenegrin A-I
1Department of Organic Chemistry, University of Debrecen, P.O. Box 20, H-4010 Debrecen, Hungary.
Archiv Der Pharmazie
|March 28, 2001
Abstract:
A series of phenylbutene and butanol derivatives (6a-j, 12, 13, 15, 17, 24b,c, 26, 27a,b) were prepared from the readily available resorcinol derivatives 2a-f and 7-hydroxy-chroman (18). The products were tested for inhibitory activity on the LPS-induced TNF-alpha production in the plasma in comparison with that of cabenegrin A-I (1a).