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Hepatic resection for metastatic tumors from noncolorectal carcinoma
1Department of Surgery, Institute of Clinical Medicine, Tsukuba University, Ten-nodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan.
Background/Aims:
The role of liver resection for hepatic metastases from noncolorectal carcinomas has yet to be clarified. The present study examines a single institutional experience of hepatic resection for noncolorectal metastases.
Methodology:
From January 1987 to March 1999, 14 patients underwent curative resection for liver metastases from noncolorectal carcinomas. Records of these patients were reviewed.
Results:
Resections were performed for liver metastases from gastric cancers (n = 8), pancreatic cancers (n = 2), and cancers of bile duct, the papilla of Vater, kidney, and breast (n = 1, each). Six patients (5 with gastric cancers and 1 with pancreas cancer) presented with synchronous disease and 8 with metachronous disease. In the gastric cancer patients, there are 2 disease-free survivors (26 and 53 months) in the metachronous group, though all of the 5 patients with synchronous disease died within 29 months. All of the 4 patients with pancreatobiliary carcinomas died within 2 years. One case of breast cancer and another of renal cell cancer are alive without disease at 49 and 9 months, respectively.
Conclusions:
For metastases from gastric cancers, better survival after hepatic resection is expected in metachronous cases than in synchronous cases. Hepatic resection may afford little benefit for patients with liver metastases from pancretobiliary cancers.
Insights
Hepatic resection for noncolorectal cancer metastases shows potential benefit in select cases. Metachronous gastric cancer metastases had better survival outcomes than synchronous ones, while pancreatobiliary cancers showed limited benefit.
Area of Science:
- Hepatobiliary Surgery
- Surgical Oncology
- Gastrointestinal Oncology
Background:
- The efficacy of liver resection for noncolorectal cancer metastases remains unclear.
- This study evaluates outcomes from a single institution's experience.
Purpose of the Study:
- To clarify the role of hepatic resection in treating liver metastases from noncolorectal carcinomas.
- To analyze survival data based on primary cancer type and disease presentation (synchronous vs. metachronous).
Main Methods:
- A retrospective review of 14 patients who underwent curative liver resection for noncolorectal metastases between 1987 and 1999.
- Analysis of patient records to determine primary cancer type, disease timing, and survival outcomes.
Main Results:
- Resections were performed for gastric (n=8), pancreatic (n=2), bile duct, Vater's papilla, kidney, and breast cancers.
- Gastric cancer metastases: 2 metachronous survivors (26, 53 months); all 5 synchronous patients died within 29 months.
- Pancreatobiliary cancers: all 4 patients died within 2 years. Renal cell and breast cancer cases showed long-term survival.
Conclusions:
- Hepatic resection for metachronous gastric cancer liver metastases may offer survival benefits.
- Limited benefit observed for liver metastases from pancreatobiliary cancers following resection.