Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue microarray: a new technology for amplification of tissue resources.

D L Rimm1, R L Camp, L A Charette

  • 1Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA.

Cancer Journal (Sudbury, Mass.)
|March 28, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SACI-IO HR+: A randomized phase II trial of sacituzumab govitecan with or without pembrolizumab in patients with metastatic hormone receptor-positive/HER2-negative breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2026
Same author

B-cell infiltration is associated with survival outcomes following programmed cell death protein 1 inhibition in head and neck squamous cell carcinoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2023
Same author

Highly sensitive quantification of optic neuritis intrathecal biomarker CXCL13.

Multiple sclerosis and related disorders·2020
Same author

Corrigendum to "Utility of CD8 score by automated quantitative image analysis in head and neck squamous cell carcinoma" [Oral Oncol. 86 (2018) 278-287].

Oral oncology·2019
Same author

Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same author

Immunological differences between primary and metastatic breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2018
Same journal

Present and Emerging Strategies for Disease Assessment in Hodgkin Lymphoma.

Cancer journal (Sudbury, Mass.)·2026
Same journal

Nodular Lymphocyte-predominant Hodgkin Lymphoma: Incidence, Pathogenesis, Management.

Cancer journal (Sudbury, Mass.)·2026
Same journal

Management of Classic Hodgkin Lymphoma in Special Clinical Situations.

Cancer journal (Sudbury, Mass.)·2026
Same journal

Older Patients With Hodgkin Lymphoma: A Contemporary Review.

Cancer journal (Sudbury, Mass.)·2026
Same journal

Adolescent and Young Adult Patients With Classical Hodgkin Lymphoma: A Review as a Case Study in AYA Cancer Care.

Cancer journal (Sudbury, Mass.)·2026
Same journal

Hodgkin Lymphoma: Management of Patients Who Fail Primary Therapy.

Cancer journal (Sudbury, Mass.)·2026
See all related articles

Tissue microarrays enable high-throughput protein expression analysis from large patient cohorts. This method maximizes tissue resources for efficient survival analysis and gene validation.

Area of Science:

  • Pathology
  • Molecular Biology
  • Biotechnology

Background:

  • Tissue microarrays (TMAs) offer a method to analyze numerous tissue samples simultaneously.
  • This technique conserves valuable tissue resources by using small tissue cores.
  • TMAs facilitate large-scale studies, such as survival analyses on hundreds of patients.

Purpose of the Study:

  • To address concerns regarding tissue representativeness and antigen preservation in TMAs.
  • To review construction and analysis strategies for TMAs.
  • To highlight the efficiency and potential of TMAs for protein expression evaluation.

Main Methods:

  • Harvesting small tissue disks from histologic sections.
  • Arranging tissue cores onto a recipient paraffin block.

Related Experiment Videos

  • Utilizing minimal antibody volumes for simultaneous analysis of hundreds of cases.

    • Main Results:

    • TMAs allow for efficient, high-throughput evaluation of protein expression in large cohorts.
    • The technique enables survival analysis on extensive patient cohorts with minimal tissue.
    • Potential for rapid validation of new genes, comparable to DNA microarray discovery rates.

    Conclusions:

    • Tissue microarrays are a powerful tool for high-throughput protein expression analysis.
    • Addressing representativeness and antigen preservation ensures the validity of TMA studies.
    • TMAs significantly enhance research efficiency in pathology and molecular biology.