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Related Experiment Videos

[Electroconvulsive therapy and serotonergic system].

N Ramírez, B Arranz, R M Dueñas

    Actas Espanolas De Psiquiatria
    |March 29, 2001
    PubMed
    Summary

    Electroconvulsive therapy (ECT) impacts neurotransmitter systems, with recent evidence highlighting serotonin as the most frequently altered neurotransmitter. This suggests serotonin pathways are key targets for understanding ECT

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    [Thoracic insufficiency syndrome].

    Acta ortopedica mexicana·2021

    Area of Science:

    • Neuroscience
    • Psychopharmacology
    • Molecular Psychiatry

    Context:

    • Electroconvulsive therapy (ECT) is a recognized treatment for severe psychiatric disorders.
    • The precise neurobiological mechanisms underlying ECT's efficacy remain under investigation.
    • Previous research implicated various neurotransmitter systems in ECT's action.

    Purpose:

    • To review and synthesize evidence on the role of neurotransmitter systems in ECT.
    • To highlight the prominent involvement of the serotonergic system in ECT.
    • To delineate the different levels at which the serotonergic system is altered by ECT.

    Summary:

    • Multiple neurotransmitter systems are involved in electroconvulsive therapy (ECT) mechanisms and efficacy.
    • Recent studies increasingly point to serotonin as the most frequently altered neurotransmitter system in ECT.
    • Alterations in the serotonergic system can occur at multiple levels: neurotransmitter/metabolite concentrations, receptor density (presynaptic/postsynaptic in brain/platelets), and intracellular signaling pathways.

    Impact:

    • Provides a comprehensive overview of neurotransmitter involvement in ECT.
    • Emphasizes the critical role of the serotonergic system in ECT's neurobiological effects.
    • Identifies specific targets within the serotonergic system for future research and potential therapeutic modulation.

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