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Related Experiment Videos

Transaminitis in Duchenne's muscular dystrophy.

S K Tay1, H T Ong, P S Low

  • 1Department of Paediatrics, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074.

Annals of the Academy of Medicine, Singapore
|March 29, 2001
PubMed
Summary
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Elevated liver enzymes in Duchenne muscular dystrophy patients are due to muscle breakdown, not liver disease. Checking creatine kinase (CK) can help diagnose muscular dystrophy.

Area of Science:

  • Neurology
  • Hepatology
  • Biochemistry

Background:

  • Persistently elevated transaminase levels often trigger investigations for liver pathology.
  • Some Duchenne muscular dystrophy patients with incidental high alanine transaminases (ALTs) underwent liver disorder investigations.

Purpose of the Study:

  • To determine transaminase levels in Duchenne muscular dystrophy patients.
  • To assess the correlation between transaminase levels and muscle enzymes like creatine kinase (CK).

Main Methods:

  • A case series involving 19 patients diagnosed with Duchenne muscular dystrophy.
  • Serum levels of alanine transaminase (ALT), aspartate transaminase (AST), and CK were measured.

Main Results:

  • Significantly elevated ALT and AST levels were observed in patients with biopsy-proven Duchenne and Becker muscular dystrophy.

Related Experiment Videos

  • ALT levels averaged 356 mmol/L (9 times the normal mean), showing a strong correlation with CK (r = 0.80, P = 0.01).
  • Transaminase levels, similar to CK, were inversely proportional to patient mobility and age.

    • Conclusions:

    • Hypertransaminasemia in muscular dystrophy patients should be attributed to muscle breakdown, not liver pathology, preventing unnecessary liver investigations.
    • In the absence of liver disease, raised transaminases may indicate occult muscular dystrophy, warranting CK level checks.