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Related Experiment Videos

Congenital complete heart block.

M C Lin1, Y C Fu, J J Tseng

  • 1Department of Pediatrics, Taichung Veterans General Hospital, 160, Sec 3, Chung-Kang Road, Taichung 407, Taiwan.

Acta Paediatrica Taiwanica = Taiwan Er Ke Yi Xue Hui Za Zhi
|March 29, 2001
PubMed
Summary
This summary is machine-generated.

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Congenital complete heart block (CCHB) in infants is linked to maternal autoantibodies, often seen in neonatal lupus. Pacemaker insertion in newborns has a high complication rate, suggesting it should be used cautiously.

Area of Science:

  • Pediatrics
  • Cardiology
  • Immunology

Background:

  • Congenital complete heart block (CCHB) is frequently associated with neonatal lupus syndrome.
  • Maternal autoantibodies play a significant role in the pathogenesis of CCHB.

Purpose of the Study:

  • To evaluate the clinical spectrum of congenital complete heart block (CCHB) in infants.
  • To investigate the association between CCHB and maternal autoantibodies.

Main Methods:

  • Retrospective analysis of nine CCHB cases diagnosed between 1994 and 1999.
  • Review of birth history, electrocardiography, Holter monitoring, pacemaker data, maternal disease, and autoantibody levels.

Main Results:

  • All nine CCHB cases were diagnosed prenatally and associated with maternal autoantibodies (ANA, anti-SSA/Ro, anti-SSB/La).

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  • Five cases (55.6%) presented with hydrops fetalis; three pregnancies were terminated.
  • Permanent pacemaker insertion in live-born infants had a 50% complication rate.

    • Conclusions:

    • Maternal autoantibodies are consistently linked to CCHB.
    • Due to high complication rates, permanent pacemaker insertion in neonates with CCHB should be reserved for specific indications.