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[Pulmonary hyalinising granuloma: report of 2 original cases with cervicofacial and orbital involvement]
R Laraki1, B Wechsler, B Bourgeon
1Service de médecine interne, hôpital de la Pitié-Salpêtrière, 83, boulevard de l'Hôpital, 75651 Paris, France.
Introduction:
Pulmonary hyalinizing granuloma is a rare fibrosing nodular disease of the lung characterized by its histological appearance, which includes at the center of the lesion a dense network of concentric hyalinized collagen lamella surrounded by perivascular lymphoplasmacytic infiltrate that rarefies in the center of the nodule.
Exegesis:
We report two new cases: the first with laryngeal (endoluminal tumor-like), orbital (subeyelid nodule) and mesenteric (9 x 6 cm mass) location of hyalinizing granuloma; the second with cervical, facial (trismus), orbital (pseudotumor) and limb (ankylosing elbow) fibrosis.
Conclusion:
The extrapulmonary diffusion of the disease is extremely rare. In one of the cases, with corticosteroids and after a follow-up of 12 months, the pulmonary tumors vanished but the fibrosis resolved only partially.