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Baroreflex sensitivity in secondary hypertension.

G Cat Genova1, F Veglio, F Rabbia

  • 1Department of Medicine and Experimental Oncology, University of Turin, Torino, Italy.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|March 29, 2001
PubMed
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Baroreceptor control is impaired in hypertension. This review examines baroreflex function in secondary hypertension, exploring potential mechanisms like arterial wall changes and hormonal influences.

Area of Science:

  • Cardiovascular Physiology
  • Hypertension Research
  • Autonomic Nervous System Function

Background:

  • Essential hypertension is linked to impaired baroreceptor control of cardiovascular functions.
  • Baroreflex alterations, including heart rate modulation and vasomotor tone control, are documented in essential hypertension.
  • Data on baroreflex function in secondary hypertension are controversial.

Purpose of the Study:

  • To review recent research on baroreflex function in secondary hypertension.
  • To explore potential mechanisms underlying baroreflex alterations in secondary hypertension.
  • To discuss whether baroreflex changes are primary or secondary to blood pressure elevation.

Main Methods:

  • Review of recent scientific literature on baroreflex function in secondary hypertension.

Related Experiment Videos

  • Analysis of studies investigating structural and functional mechanisms.
  • Synthesis of findings regarding the relationship between baroreflex changes and blood pressure.

    • Main Results:

    • Baroreflex alterations are observed in secondary hypertension, though data remain controversial.
    • Potential mechanisms include structural changes (decreased vascular distensibility) and functional factors (angiotensin II, aldosterone, catecholamines, nitric oxide).
    • The primary cause of baroreflex changes in secondary hypertension versus a consequence of elevated blood pressure is not definitively established.

    Conclusions:

    • Baroreflex function is altered in secondary hypertension, with proposed mechanisms involving vascular and hormonal factors.
    • Further research is needed to elucidate whether these baroreflex changes are a cause or consequence of the hypertensive condition.
    • Understanding these mechanisms is crucial for managing secondary hypertension and its cardiovascular implications.