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Relatedness between the coagulase gene 3'-end region and coagulase serotypes among Staphylococcus aureus strains
K Kanemitsu1, H Yamamoto, H Takemura
1Department of Microbiology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan. k2kane@marianna-u.ac.jp
Microbiology and Immunology
|March 29, 2001
Abstract:
The 3'-end region of the coagulase gene from 22 strains of Staphylococcus aureus including 10 standard serotype strains was sequenced, and five subgroups with 4-8 tandem repeating units were distinguished among the tested strains. Phylogenetic analysis of the 3'-end region of the coagulase gene indicated that strains belonging to the same serotype were clustered in the same branch. A phylogenetic tree of the deduced amino acid sequences revealed that the C-terminal region might not be responsible for the epitope of the coagulase protein.