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Updated: Aug 11, 2026

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Published on: January 17, 2018
Transient hyponatriemia complicated by seizures after endoscopic third ventriculostomy
1Department of Neurosurgery, Neurological Institute of New Jersey, University of Medicine and Dentistry of New Jersey, Newark, USA.
This study reports a rare complication after endoscopic third ventriculostomy in an infant: syndrome of inappropriate antidiuretic hormone secretion causing hyponatriemia and seizures. Close monitoring of electrolytes post-surgery is crucial.
Area of Science:
- Neurosurgery
- Pediatric Neurology
- Endocrinology
Background:
- Hydrocephalus in infants often requires surgical intervention.
- Aqueductal stenosis is a common cause of obstructive hydrocephalus.
- Endoscopic third ventriculostomy (ETV) is a minimally invasive surgical procedure for treating hydrocephalus.
Observation:
- An infant underwent ETV for symptomatic hydrocephalus due to aqueductal stenosis.
- The infant developed syndrome of inappropriate antidiuretic hormone secretion (SIADH).
- SIADH led to severe hyponatriemia and seizures postoperatively.
Findings:
- This is the first reported case of SIADH and subsequent hyponatremic seizures following ETV.
- Neuroendoscopic procedures carry the risk of specific neuroendocrine complications.
- Infants may be particularly vulnerable to electrolyte disturbances after neurosurgery.
Implications:
- Neurosurgeons should be aware of the potential for SIADH after ETV.
- Close monitoring of serum electrolytes is essential in the acute postoperative period for infants.
- Early detection and management of hyponatriemia can prevent neurological complications like seizures.
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