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Related Experiment Videos

Trimodality therapy for advanced gallbladder cancer.

A R Sasson1, J P Hoffman, E Ross

  • 1Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

The American Surgeon
|March 29, 2001
PubMed
Summary
This summary is machine-generated.

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Advanced gallbladder cancer (stage III, IV, or recurrent) treated with trimodality therapy, including surgery, radiotherapy, and chemotherapy, shows potential for prolonged survival in selected patients.

Area of Science:

  • Surgical Oncology
  • Gastrointestinal Oncology
  • Cancer Treatment Modalities

Background:

  • Gallbladder carcinoma, particularly advanced stages (III, IV) and recurrent disease, presents significant treatment challenges.
  • Surgical extirpation is a cornerstone for potentially curative treatment, but outcomes in advanced disease remain limited.

Purpose of the Study:

  • To evaluate the efficacy of trimodality therapy (surgery, radiotherapy, chemotherapy) in patients with advanced or recurrent gallbladder cancer.
  • To assess survival outcomes and disease-free intervals following aggressive surgical management and adjuvant therapies.

Main Methods:

  • Retrospective review of ten patients with stage III, IV, or recurrent gallbladder carcinoma undergoing surgical resection between 1991 and 1999.
  • Surgical procedures included cholecystectomy, liver resection, regional lymphadenectomy, and en bloc resection of contiguous structures.

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  • All patients received adjuvant radiotherapy; 90% received chemotherapy.

    • Main Results:

    • Median overall survival was 53.6 months (excluding perioperative mortality).
    • Four patients survived over 4 years, with four currently alive and disease-free at varying intervals (up to 73 months).
    • Median disease-free interval after resection of recurrent disease was 13.8 months.

    Conclusions:

    • Trimodality therapy, incorporating aggressive surgical resection and adjuvant chemoradiotherapy, is feasible in selected patients with advanced or recurrent gallbladder cancer.
    • This multimodal approach may lead to prolonged survival and disease control in this challenging patient population.