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Related Experiment Videos

Neutrophil elastase and obliterative bronchiolitis.

J P Scott1, D W Holt, J Wallwork

  • 1Division of Thoracic Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.

Transplant International : Official Journal of the European Society for Organ Transplantation
|January 1, 1994
PubMed
Summary
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Neutrophil elastase elevations correlate with lung function decline and fibrosis in transplant recipients. This suggests elastase plays a role in the development of obliterative bronchiolitis, a serious lung condition.

Area of Science:

  • Pulmonary Medicine
  • Transplant Immunology
  • Biochemistry

Background:

  • Obliterative bronchiolitis (OB) is a significant cause of graft loss after lung transplantation.
  • The precise mechanisms driving OB pathogenesis remain incompletely understood.
  • Neutrophil elastase and fibrosis markers like hyaluronate (HA) are implicated in lung injury.

Purpose of the Study:

  • To investigate the relationship between bronchoalveolar lavage (BAL) elastase levels and the development of OB.
  • To determine the temporal association of elastase activity with lung function decline (FEV1) and fibrosis (HA levels).

Main Methods:

  • BAL fluid was collected from 48 lung transplant recipients.
  • Elastase levels were assayed.
  • Hyaluronate (HA) levels were measured as a marker of fibrosis.

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  • Forced expiratory volume in 1 second (FEV1) was monitored.
  • Regression analysis was used to correlate variables.

    • Main Results:

    • High elastase levels were observed during active decline in lung function.
    • Elevated elastase levels were associated with increased HA levels, indicating concurrent fibrosis.
    • A significant correlation was found between elastase, HA, and reduced FEV1.

    Conclusions:

    • Intense neutrophil elastase release occurs concurrently with the clinical development of OB.
    • Neutrophil elastase may actively contribute to the destruction of bronchiolar architecture in OB.
    • Targeting neutrophil elastase could be a potential therapeutic strategy for preventing or treating OB.