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Up-regulation of cyclooxygenase-2 in inflammatory demyelinating neuropathy
T Kawasaki1, N Oka, I Akiguchi
1Department of Neurology, Graduate School of Medicine, Kyoto University, Japan.
Acta Neuropathologica
|March 29, 2001
Abstract:
To clarify the role of prostaglandins in peripheral nerve demyelination, we examined the expression of cyclooxygenase-2 (COX-2) using selected nerve specimens from patients with chronic inflammatory demyelinating polyneuropathy. COX-2 protein was up-regulated in macrophages causing active demyelination. In situ hybridization revealed that COX-2 mRNA signals were strongly expressed on macrophages adhering to the demyelinating nerve fibers at the endoneurium. This observation may provide a rationale for application of neuroprotective strategies employing COX-2 inhibitors in inflammatory demyelinating neuropathies.