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Updated: Aug 7, 2026

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
Published on: September 6, 2012
Dendrimers and hyperbranched polymers as high-loading supports for organic synthesis
1Freiburger Materialforschungszentrum und Institut für Makromolekulare Chemie, Albert-Ludwigs-Universität Freiburg, Germany. haag@fmf.uni-freiburg.de
Abstract:
Polymeric supports have become a big necessity for automated synthesis and combinatorial chemistry, yet, the loading capacities of most polystyrene resins are very limited (typically < 1.5 mmol x g(-1)). Dendrimers and hyperbranched polymers have been discussed for this application and now became readily available. These soluble polymers can either be used directly as high-loading supports for substrates, reagents, and catalysts or alternatively in hybrid polymers linked to conventional polystyrene resins.
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