Correlation between clinical activity score and thyroid autoantibodies in patients with thyroid ophthalmopathy

To investigate the relation between clinical activity score (CAS) and thyroid autoantibodies of thyroid ophthalmopathy, we measured the level of TSH receptor antibody (TRAb), antithyroglobulin antibody (ATA), and antimicrosomal antibody (AMA) in 41 patients with thyroid ophthalmopathy. The results of thyroid autoantibodies level were compared with CAS. Under the multiple regression and correlation analysis among CAS and the levels of TRAb, ATA, and AMA, no correlation was shown in this study. In conclusion, there is no correlation of thyroid ophthalmopathy among CAS and the levels of TRAb, ATA, and AMA in our study. If we use these three kinds of thyroid autoantibodies to match the activity of thyroid ophthalmopathy, it seems to be inappropriate. Further search of other simplified index to reflect the activity of ophthalmopathy should be encouraged.