Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Second primary glioblastoma.

R M Reis¹, R Herva, S Brandner

¹International Agency for Research on Cancer, Lyon, France.

Journal of Neuropathology and Experimental Neurology

|March 29, 2001

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Measurement of x-ray bremsstrahlung radiation from high energy electrons by stochastic acceleration in Heliotron J.

The Review of scientific instruments·2025

Same author

Correction: Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma.

Oncogene·2022

Same author

Epigenetic silencing of miRNA-9 is associated with HES1 oncogenic activity and poor prognosis of medulloblastoma.

British journal of cancer·2013

Same author

Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity.

Neuropathology and applied neurobiology·2013

Same author

Long-term health-related quality of life of surgically treated pituitary adenoma patients: a descriptive study.

ISRN endocrinology·2013

Same author

Persistence of alkylated DNA bases in the Mongolian gerbil (Meriones unguiculatus) following a single dose of methylnitrosourea +.

Carcinogenesis·2012

Same journal

An unusual extra-axial supratentorial presentation of atypical teratoid/rhabdoid tumor in a child.

Journal of neuropathology and experimental neurology·2026

Same journal

Primary intracranial sarcoma, DICER1-mutant: 5 cases highlighting variable clinical and molecular features.

Journal of neuropathology and experimental neurology·2026

Same journal

Novel YWHAE-NTRK3 fusion in a pediatric glioma.

Journal of neuropathology and experimental neurology·2026

Same journal

Comprehensive clinicomolecular characterization of a methylation-defined supratentorial high-grade astrocytoma with piloid features in a young adult with confirmed germline NF1 mutation.

Journal of neuropathology and experimental neurology·2026

Same journal

Spatial mapping, isolation, and culture of primary human microglia and astrocytes: A systematic review and framework for glial cell-based models.

Journal of neuropathology and experimental neurology·2026

Same journal

Multiparameter flow cytometry of CSF identifies elevated CD8+ effector memory and TEMRA T-cells in immune-mediated neurologic disorders.

Journal of neuropathology and experimental neurology·2026

See all related articles

A patient developed two distinct glioblastomas years apart, each with unique genetic mutations in tumor suppressor genes like p53 and PTEN. This suggests glioblastomas may arise independently, challenging the monoclonal origin theory.

Area of Science:

Neuro-oncology
Cancer Genetics
Molecular Biology

Background:

Glioblastomas are typically considered to originate from a single clone, despite their genetic heterogeneity.
Understanding the origin of multiple glioblastomas is crucial for diagnosis and treatment strategies.

Observation:

A 64-year-old patient developed a second glioblastoma 10 years after resection of a primary tumor.
Both glioblastomas exhibited distinct mutation profiles in tumor suppressor genes, including p53 and PTEN.
Both tumors shared a homozygous p16 deletion.

Findings:

The differing mutation patterns in p53 and PTEN between the two glioblastomas indicate they are independent neoplasms, not a recurrence.
The presence of multiple mutations in tumor suppressor genes suggests a potential novel disease mechanism.

Related Experiment Videos

No evidence of DNA mismatch repair deficiency or inherited cancer syndromes was found.

Implications:

This case challenges the traditional view of glioblastomas as strictly monoclonal in origin.
The findings may necessitate a re-evaluation of diagnostic criteria and therapeutic approaches for patients with multiple brain tumors.
Further research into the mechanisms underlying independent glioblastoma development is warranted.