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Updated: Jul 8, 2026
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Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
Herpes simplex virus 1 transmission through corneal transplantation
Lancet (London, England)
|March 29, 2001
Summary
Herpes simplex virus type 1 (HSV-1) can transmit through corneal transplants. This study confirms donor-derived HSV-1 reactivation after penetrating keratoplasty.
Area of Science:
- Ophthalmology
- Virology
- Microbiology
Background:
- Herpes simplex virus type 1 (HSV-1) is a common cause of corneal infections.
- Corneal transplantation (keratoplasty) is a procedure to restore vision.
- Transmission routes of HSV-1 in corneal grafts are not fully understood.
Observation:
- HSV-1 DNA was analyzed in donor and recipient corneas before and after transplantation.
- Genetic analysis of HSV-1 DNA was performed.
Findings:
- The study provides conclusive evidence of HSV-1 transmission via penetrating keratoplasty.
- Donor-derived HSV-1 was detected in the recipient cornea post-transplantation.
- Reactivation of the transmitted HSV-1 occurred in the transplanted cornea.
Implications:
- Corneal transplantation poses a risk for HSV-1 transmission.
- Screening protocols for donor corneas may need re-evaluation.
- Understanding transmission pathways is crucial for preventing post-keratoplasty HSV-1 infections.
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