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Diagnostic yield in computed tomography guided stereotactic biopsies.

M C Sharma1, A Singh, A Verma

  • 1Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi-110029, India.

The Journal of the Association of Physicians of India
|March 29, 2001
PubMed
Summary

Computerized tomography (CT) guided stereotactic biopsies achieved a high diagnostic yield for brain lesions, particularly from the lesion center. This method is effective for diagnosing brain tumors like astrocytoma.

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Area of Science:

  • Neurosurgery
  • Neuroradiology
  • Neuropathology

Background:

  • Stereotactic biopsy is a crucial diagnostic tool for intracranial lesions.
  • Accurate tissue sampling is essential for definitive pathological diagnosis and treatment planning.
  • Computerized tomography (CT) guidance enhances the precision of stereotactic biopsies.

Purpose of the Study:

  • To evaluate the diagnostic yield and safety of CT-guided stereotactic biopsies.
  • To determine the optimal sampling location within brain lesions.
  • To assess the rate of definitive pathological diagnosis and postoperative complications.

Main Methods:

  • Fifty-three patients underwent CT-guided stereotactic biopsies using the Leksell stereotactic apparatus.
  • Biopsies were taken from different CT-defined zones: center, periphery, and perilesional areas.

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  • Histological diagnoses were correlated with imaging findings.

    • Main Results:

    • The overall diagnostic yield was 98.2%, with the highest yield from the lesion center (92.1%).
    • Astrocytoma was the most common histological diagnosis, with the thalamus being the most frequent tumor site.
    • A definite pathological diagnosis was achieved in 81.1% of cases, with a 3.7% mortality rate.

    Conclusions:

    • CT-guided stereotactic biopsy is a highly effective and safe procedure for diagnosing brain lesions.
    • Sampling from the center of the lesion maximizes diagnostic yield.
    • The procedure facilitates definitive pathological diagnosis, guiding subsequent patient management.