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Related Experiment Video

Updated: Jun 25, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

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Published on: October 12, 2012

Voluven, a lower substituted novel hydroxyethyl starch (HES 130/0.4), causes fewer effects on coagulation in major

O Langeron¹, M Doelberg, E T Ang

¹Département d'Anesthésie-Réanimation, Centre Hospitalo-universitaire (CHU) Pitié-Salpêtrière, Paris, France.

Anesthesia and Analgesia

|March 29, 2001

Summary

This summary is machine-generated.

A new Hydroxyethyl Starch (HES) solution, Voluven, shows comparable efficacy to HAES-steril for plasma volume expansion. Voluven may reduce coagulation impairment and the need for allogeneic blood transfusions in major orthopedic surgery.

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Area of Science:

Anesthesiology and Critical Care Medicine
Pharmacology and Therapeutics

Background:

Hydroxyethyl starch (HES) solutions are widely used as plasma volume expanders.
High doses of HES can impair coagulation, particularly during perioperative periods.
A novel, lower-substituted HES (Voluven) was developed to minimize hemostatic interactions.

Purpose of the Study:

To compare the safety and efficacy of Voluven with HAES-steril (pentastarch) in major orthopedic surgery.
To evaluate the impact of Voluven on coagulation parameters compared to HAES-steril.

Main Methods:

Prospective, randomized, double-blinded study involving 100 major orthopedic surgery patients.
Equivalence of efficacy was established by comparing Voluven and HAES-steril within a predefined range.
Coagulation factor VIII levels and partial thromboplastin time were monitored postoperatively.

Main Results:

Comparable efficacy was demonstrated between Voluven and HAES-steril, with the 95% confidence interval within the equivalence range.
Voluven showed significantly less interference with coagulation factor VIII and partial thromboplastin time compared to HAES-steril.
While total red blood cell transfusion amounts were similar, the Voluven group required significantly fewer homologous red blood cell transfusions.

Conclusions:

Voluven offers comparable efficacy to HAES-steril as a plasma volume expander in large-blood-loss surgery.
Voluven may lead to reduced coagulation impairment and a potential decrease in allogeneic blood transfusions.
The novel HES formulation demonstrates a favorable safety profile regarding hemostatic interactions.