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Local anesthetics attenuate lysophosphatidic acid-induced priming in human neutrophils

L G Fischer1, M Bremer, E J Coleman

  • 1Department of Anesthesiology, University Hospital Maastricht, The Netherlands.

Anesthesia and Analgesia
|March 29, 2001
PubMed
Abstract

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Local anesthetics (LAs) block sensory and motor impulses by inhibiting the sodium channels on the nerve cell membranes. This induces temporary loss of sensation, relieving pain in a specific body area.
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The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
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