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Related Experiment Videos

Intravenous ketoprofen in thyroid and parathyroid surgery.

E R Basto1, C Waintrop, F D Mourey

  • 1Department of Anesthesiology and Intensive Care, Saint-Louis University Hospital, Paris, France.

Anesthesia and Analgesia
|March 29, 2001
PubMed
Summary

Ketoprofen combined with propacetamol effectively reduced postoperative pain and nausea after thyroid and parathyroid surgery. This combination also decreased morphine requirements without increasing cervical bleeding risks.

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Area of Science:

  • Anesthesiology
  • Surgical Pain Management
  • Pharmacology

Background:

  • Postoperative pain management after thyroid and parathyroid surgery often involves multimodal analgesia.
  • Non-steroidal anti-inflammatory drugs (NSAIDs) like ketoprofen may offer benefits but their impact on bleeding risk in this specific surgery is a concern.

Purpose of the Study:

  • To evaluate the efficacy and safety of ketoprofen-propacetamol combination versus propacetamol alone for postoperative pain, bleeding, and nausea/vomiting after thyroid and parathyroid surgery.

Main Methods:

  • A prospective open study comparing two groups: one receiving ketoprofen-propacetamol and a control group receiving propacetamol alone.
  • Standardized anesthetic techniques and postoperative analgesia protocols were used, with morphine rescue for pain scores above 40.

Related Experiment Videos

  • Pain scores, opioid consumption, and cervical drainage fluid (volume, hemoglobin concentration, and mass) were recorded over 24 hours.

    • Main Results:

    • The ketoprofen group reported significantly lower pain scores and required less morphine (7.4 vs 11.7 mg).
    • Fewer episodes of nausea and vomiting were observed in the ketoprofen group (21 vs 38).
    • No significant difference in cervical bleeding was found between groups, though two hematomas occurred in the control group.

    Conclusions:

    • Ketoprofen, when combined with propacetamol, effectively reduces postoperative pain and associated adverse effects like nausea and vomiting.
    • The ketoprofen-propacetamol combination appears safe for thyroid and parathyroid surgery, showing no increased risk of cervical bleeding.