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Related Experiment Videos

Fetal lung volume: estimation at MR imaging-initial results.

F Rypens1, T Metens, N Rocourt

  • 1Departments of Radiology, Hôpital Erasme, Université Libre de Bruxelles, route de Lennik 808, B-1070 Brussels, Belgium.

Radiology
|March 29, 2001
PubMed
Summary

Fetal lung volume (FLV) can be accurately measured using MRI. This study establishes normal FLV ranges and shows its potential for diagnosing lung hypoplasia in fetuses with malformations.

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Area of Science:

  • Medical imaging
  • Fetal medicine
  • Quantitative MRI

Background:

  • Accurate assessment of fetal lung volume (FLV) is crucial for diagnosing lung hypoplasia.
  • Magnetic resonance (MR) imaging offers a non-invasive method for in utero fetal assessment.

Purpose of the Study:

  • To establish a normative curve for fetal lung volume (FLV) using fast spin-echo MR imaging across gestational ages (21-38 weeks).
  • To explore correlations between fetal lung growth and presentation, sex, and ultrasonographic biometric measurements.
  • To evaluate the utility of MR-derived FLV in fetuses with thoracoabdominal malformations.

Main Methods:

  • A prospective multicenter study involving 336 fetuses underwent T2-weighted MR imaging.
  • Data from 215 fetuses without malformations and with normal US biometry were used to create the normative FLV curve.

Related Experiment Videos

  • MR FLV measurements were validated against pathologic examination in 11 fetuses and compared to normative values in 16 fetuses with malformations.

    • Main Results:

    • Normal FLV demonstrated a power-law increase with gestational age, with increasing variability at later stages.
    • Interobserver reliability for FLV measurements was excellent (R² = 0.96).
    • MR FLV measurements were approximately 90% of those obtained via pathologic examination, with a consistent left-to-right FLV ratio of 0.78.
    • Fetuses with diaphragmatic hernia exhibited the lowest FLV values, while those with cystic adenomatoid malformations showed normal FLV.

    Conclusions:

    • Fast spin-echo T2-weighted MR imaging provides an effective method for in utero assessment of normal fetal lung volume distribution against gestational age.
    • These findings support the potential of using normative FLV values derived from MR imaging to identify fetuses at risk for lung hypoplasia.