Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quantifiable dose-dependent withdrawal after morphine discontinuation in a rat model.

L Langerman1, B Piscoun, M Bansinath

  • 1The Department of Anesthesiology, New York University Medical Center, 550 First Ave., New York, NY 10016, USA. levl@hotmail.com

Pharmacology, Biochemistry, and Behavior
|March 29, 2001
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transnasal topical sphenopalatine ganglion block to treat tension headache in a pregnant patient.

International journal of obstetric anesthesia·2014
Same author

A critical analysis of the experimental evaluation of nociceptive reactions in animals.

Pharmaceutical research·2013
Same author

Use of statistical checks as maintenance tools for TLD readers.

Radiation protection dosimetry·2007
Same author

Satisfaction with epidural and intravenous patient-controlled analgesia.

Pain medicine (Malden, Mass.)·2004
Same author

Analgesic duration and kinetics of liposomal bupivacaine after subcutaneous injection in mice.

Clinical and experimental pharmacology & physiology·2003
Same author

Intrathecal administration of liposomal neostigmine prolongs analgesia in mice.

Acta anaesthesiologica Scandinavica·2002

This study shows that rats experiencing morphine withdrawal exhibit significant weight loss and reduced food/water intake. These withdrawal symptoms correlate with morphine concentration, validating a rat model for studying opiate withdrawal.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Animal Models

Background:

  • Opioid addiction is a significant public health concern.
  • Understanding the physiological manifestations of opioid withdrawal is crucial for developing effective treatments.
  • Animal models are essential for studying the complex mechanisms of addiction and withdrawal.

Purpose of the Study:

  • To evaluate the intensity of withdrawal symptoms in rats following morphine infusion discontinuation.
  • To establish a quantifiable rat model for assessing spontaneous withdrawal from opiates.

Main Methods:

  • Opiate addiction was induced in rats via progressively increasing intraperitoneal morphine infusion.
  • Control rats received normal saline infusions.
  • Withdrawal symptoms were assessed by monitoring body weight reduction, food consumption, and water intake post-infusion discontinuation.

Related Experiment Videos

Main Results:

  • All morphine-infused groups exhibited significant body weight reduction in the four days after infusion cessation.
  • A decline in food and water intake was observed on the first day post-discontinuation.
  • The severity of these withdrawal signs was directly dependent on the morphine infusion concentration.

Conclusions:

  • The rat model employed in this study effectively demonstrates quantifiable spontaneous withdrawal symptoms.
  • This model holds potential for further research into the neurobiology of opiate withdrawal and the efficacy of potential interventions.