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Retinal oxygenation via the choroidal circulation.

M B Landers

    Transactions of the American Ophthalmological Society
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Normal oxygen levels in the inner retina can be restored during retinal arterial obstruction by breathing 100% oxygen. However, this is not possible if choroidal circulation is also blocked.

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    Area of Science:

    • Ophthalmology
    • Retinal Physiology
    • Neuroscience

    Background:

    • Retinal arterial obstruction compromises oxygen supply to inner retinal layers.
    • The choroid is a primary source of oxygen for the outer retina, but its contribution to inner retinal oxygenation during obstruction is unclear.

    Purpose of the Study:

    • To investigate the potential of choroidal diffusion to supply oxygen to the inner retina during retinal arterial obstruction.
    • To assess the impact of oxygen levels on retinal function under these conditions.

    Main Methods:

    • Experiments were conducted on anesthetized cats and rhesus monkeys.
    • Oxygen levels in the vitreous cavity were monitored using an oxygen electrode.
    • Retinal arterial circulation was occluded using a probe, and choroidal circulation was occluded by elevating intraocular pressure.

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  • Inspired oxygen concentration was varied between 20% and 100%.

    • Main Results:

    • Breathing 100% oxygen restored inner retinal oxygen tension during retinal arterial occlusion alone.
    • This restoration was not possible when choroidal circulation was also occluded (intraocular pressure elevated to 85 mm Hg).
    • Electroretinogram and visually evoked responses, extinguished by arterial occlusion and 20% oxygen, were restored by 100% oxygen.

    Conclusions:

    • Choroidal diffusion can adequately supply oxygen to the inner retina during retinal arterial obstruction when choroidal circulation is intact.
    • Maintaining adequate oxygenation via inspired air is crucial for retinal function during arterial occlusion.