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Updated: Aug 9, 2026

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Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Chromatographic separation and spectrometric identification of the oxidation products from a tetrahydro-isoquinoline
1Analytical R&D, Skin Research Center, Johnson & Johnson Consumer Products Worldwide, Skillman, New Jersey 08558, USA. fzhang1@cpcus.jnj.com
Journal of Pharmaceutical and Biomedical Analysis
|March 29, 2001
Abstract:
The oxidation chemistry of 3',4'-deoxynorlaudanosoline carboxylic acid, a tetrahydroisoquinoline alkaloid, has been studied by electrochemical approaches. Four reaction products were isolated by semi-preparative high performance liquid chromatography and identified structurally by nuclear magnetic resonance, mass spectrometry, ultraviolet-visible spectrophotometry and electrochemistry studies. An oxidation mechanism was proposed.

