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Fluoride deposition in the aged human pineal gland
1School of Biological Sciences, University of Surrey, Guildford, UK. jenniluke@compuserve.com
Caries Research
|March 29, 2001
Summary
Aged human pineal glands accumulate significant fluoride (F). Fluoride concentration in the pineal gland correlates positively with calcium levels, suggesting a unique accumulation pathway independent of bone fluoride.
Area of Science:
- Biochemistry
- Human Anatomy
- Toxicology
Background:
- The pineal gland's role in aging and potential calcification is under investigation.
- Understanding trace element accumulation in aging tissues is crucial for health research.
Purpose of the Study:
- To determine fluoride (F) accumulation in the aged human pineal gland.
- To compare fluoride concentrations in the pineal gland, muscle, and bone.
- To assess the relationship between fluoride and calcium in the pineal gland.
Main Methods:
- Dissection of pineal gland, muscle, and bone from 11 aged cadavers.
- Fluoride assay using HMDS-facilitated diffusion and F-ion-specific electrode.
- Calcium determination via atomic absorption spectroscopy.
Main Results:
- Aged pineal glands showed high fluoride concentrations (297 mg F/kg wet weight).
- Pineal gland calcium levels were significantly elevated (16,000 mg Ca/kg wet weight).
- A positive correlation was observed between pineal fluoride and calcium (r=0.73, p<0.02).
Conclusions:
- The aged human pineal gland readily accumulates fluoride.
- Pineal fluoride accumulation appears linked to calcium levels, distinct from bone accumulation.
- The elevated F/Ca ratio in the pineal gland suggests a specific biological mechanism.