Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Possible antineoplastic agents I.

A U De, D Pal

    Journal of Pharmaceutical Sciences
    |February 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Researchers synthesized thalidomide and glutarimide derivatives, finding several compounds showed significant antineoplastic activity against Ehrlich ascites carcinoma in mice.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Imaging features and management of tuberculomas: a review of cases and literature.

    Clinical radiology·2025
    Same author

    Imaging Brain Tissue with Quantum Light at Low Power.

    The journal of physical chemistry. B·2024
    Same author

    Exploring the role of oxygen vacancies on the magnetic and electromagnetic absorption properties of La<sup>3+</sup>-modified M-type hexaferrite with Al<sup>3+</sup>doping.

    Journal of physics. Condensed matter : an Institute of Physics journal·2023
    Same author

    Exploration of low field magnetic states in Nd1-xCe<sub></sub>CrO<sub>3</sub>.

    Journal of physics. Condensed matter : an Institute of Physics journal·2023
    Same author

    Mathematical Analysis of a COVID-19 Epidemic Model by Using Data Driven Epidemiological Parameters of Diseases Spread in India.

    Biophysics·2022
    Same author

    Spin-state transition of Co ion (<i>S</i><b>=</b>2<b>→</b><i>S</i><b>=</b>5/2) in hole substituted 1D chain of Ca<sub>3</sub>Co<sub>2</sub>O<sub>6</sub>.

    Journal of physics. Condensed matter : an Institute of Physics journal·2022
    Same journal

    Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

    Journal of pharmaceutical sciences·2026
    Same journal

    Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

    Journal of pharmaceutical sciences·2026
    Same journal

    Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

    Journal of pharmaceutical sciences·2026
    Same journal

    Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

    Journal of pharmaceutical sciences·2026
    Same journal

    A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

    Journal of pharmaceutical sciences·2026
    Same journal

    Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

    Journal of pharmaceutical sciences·2026
    See all related articles

    Area of Science:

    • Medicinal Chemistry
    • Pharmacology
    • Oncology

    Background:

    • Thalidomide and glutarimide derivatives are classes of compounds with diverse biological activities.
    • Ehrlich ascites carcinoma is a widely used murine model for evaluating anticancer drug efficacy.

    Purpose of the Study:

    • To synthesize novel thalidomide and glutarimide derivatives.
    • To evaluate the antineoplastic potential of these synthesized compounds against Ehrlich ascites carcinoma.

    Main Methods:

    • Chemical synthesis of selected thalidomide and glutarimide analogs.
    • In vivo efficacy testing of synthesized compounds in Swiss albino mice bearing Ehrlich ascites carcinoma.

    Main Results:

    • Several synthesized thalidomide and glutarimide derivatives demonstrated notable antineoplastic effects.

    Related Experiment Videos

  • The compounds showed significant inhibition of tumor growth in the Ehrlich ascites carcinoma model.

    • Conclusions:

    • The synthesized thalidomide and glutarimide derivatives represent promising candidates for further investigation as anticancer agents.
    • This study highlights the potential of these chemical scaffolds in developing novel cancer therapeutics.