Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A flexible design for multiple armed screening trials.

D J Sargent1, R M Goldberg

  • 1Section of Biostatistics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA. sargent.daniel@mayo.edu

Statistics in Medicine
|March 29, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of tumor and node stages on the efficacy of adjuvant oxaliplatin-based chemotherapy in stage III colon cancer patients: an ACCENT pooled analysis.

ESMO open·2025
Same author

Different prognostic values of KRAS exon 2 submutations and BRAF V600E mutation in microsatellite stable (MSS) and unstable (MSI) stage III colon cancer: an ACCENT/IDEA pooled analysis of seven trials.

Annals of oncology : official journal of the European Society for Medical Oncology·2023
Same author

Evaluation of the change of outcomes over a 10-year period in patients with stage III colon cancer: pooled analysis of 6501 patients treated with fluorouracil, leucovorin, and oxaliplatin in the ACCENT database.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Prognostic value of primary tumour resection in synchronous metastatic colorectal cancer: Individual patient data analysis of first-line randomised trials from the ARCAD database.

European journal of cancer (Oxford, England : 1990)·2018
Same author

Cancer-Associated Anorexia and Cachexia : Implications for Drug Therapy.

Drugs·2017
Same author

Statistical controversies in clinical research: basket trials, umbrella trials, and other master protocols: a review and examples.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same journal

Optimal Weighted Tests for Replication Studies and the 'Two-Trials Rule' With Multiple Hypotheses.

Statistics in medicine·2026
Same journal

Identifiable Copula-Double-Cox Models: A Fully Parametric Framework for Dependent Right-Censored Survival Data.

Statistics in medicine·2026
Same journal

Moving From Individualized Risk-Based Prevention to Benefit-Based Prevention: Estimating Individualized Life-Years Gained From Prevention Services as a Basis for Eligibility.

Statistics in medicine·2026
Same journal

A Mixture of Distributed Lag Non-Linear Models to Account for Spatially Heterogeneous Exposure-Lag-Response Associations.

Statistics in medicine·2026
Same journal

Practical Considerations for Gaussian Process Modeling for Causal Inference in Quasi-Experimental Studies With Panel Data.

Statistics in medicine·2026
Same journal

Covariate Adjustment for Wilcoxon Two Sample Statistic and Test.

Statistics in medicine·2026
See all related articles

This study introduces a flexible screening trial design for phase II clinical trials. It uses a decision rule to select promising treatments, avoiding inferior options while mirroring real-world clinical practice.

Area of Science:

  • Clinical Trials
  • Biostatistics
  • Pharmaceutical Research

Background:

  • Screening trials in phase II aim to select treatments for phase III trials.
  • Current methods may require a higher level of evidence than necessary for initial selection.
  • Clinical decision-making often incorporates factors beyond just success probability.

Purpose of the Study:

  • Introduce a flexible phase II screening trial design.
  • Propose a decision rule to guide treatment selection.
  • Align trial design with practical clinical decision-making.

Main Methods:

  • Utilizes a flexible design incorporating a specific decision rule.
  • The rule selects the highest observed success rate if the difference exceeds a threshold (d).

Related Experiment Videos

  • Allows consideration of other factors if the observed difference is below the threshold.

    • Main Results:

    • The proposed design offers flexibility in treatment selection.
    • It aims to avoid selecting substantially inferior treatments.
    • The decision rule balances statistical evidence with clinical judgment.

    Conclusions:

    • The flexible screening trial design enhances phase II trial efficiency.
    • The proposed decision rule supports practical treatment selection.
    • This approach better reflects the multifaceted nature of clinical treatment recommendations.