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Related Experiment Videos

Phytotherapy for benign prostatic hyperplasia.

T J Wilt1, A Ishani, I Rutks

  • 1Minneapolis VA Center for Chronic Diseases Outcomes Research, MN 55417, USA. wilt.timothy@minneapolis.va.gov

Public Health Nutrition
|March 29, 2001
PubMed
Summary
This summary is machine-generated.

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Serenoa repens and Hypoxis rooperi show efficacy in treating benign prostatic hyperplasia (BPH) symptoms and improving urinary flow. Phytotherapies are generally well-tolerated with mild side effects, offering a cost-effective BPH treatment option.

Area of Science:

  • Urology
  • Pharmacology
  • Evidence-based Medicine

Background:

  • Benign prostatic hyperplasia (BPH) is a common condition in aging men.
  • Phytotherapeutic compounds are increasingly used for symptomatic BPH management.
  • Evidence for the efficacy and safety of these agents requires systematic evaluation.

Purpose of the Study:

  • To systematically review randomized trials on phytotherapeutic compounds for symptomatic benign prostatic hyperplasia (BPH).
  • To assess the efficacy and safety of commonly used plant-based BPH treatments.

Main Methods:

  • Systematic review of randomized controlled trials identified through comprehensive database searches (MEDLINE, EMBASE, Cochrane Library, etc.).
  • Inclusion criteria focused on symptomatic BPH, phytotherapeutic interventions, placebo or pharmacologic controls, and minimum 30-day treatment duration.

Related Experiment Videos

  • Data extraction was performed independently by two investigators.

    • Main Results:

    • Forty-four studies evaluated six agents: Serenoa repens, Hypoxis rooperi, Secale cereale, Pygeum africanum, Urtica dioica, and Curcubita pepo.
    • Serenoa repens demonstrated significant improvements in urinary tract symptoms and flow measures compared to placebo, with efficacy comparable to finasteride.
    • Hypoxis rooperi also showed effectiveness in improving BPH symptoms and flow.
    • Secale cereale modestly improved symptoms, while Pygeum africanum's efficacy is limited by reporting issues.
    • Urtica dioica and Curcubita pepo showed limited evidence for monotherapy.

    Conclusions:

    • Serenoa repens offers the strongest evidence for efficacy and tolerability in BPH treatment among reviewed phytotherapies.
    • Hypoxis rooperi and Secale cereale show promise, but with less robust evidence.
    • Further high-quality, long-term trials with standardized preparations are needed for definitive conclusions on phytotherapies for BPH.