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The genetics of panic disorder.

C T Finn1, J W Smoller

  • 1Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, WACC-812, Boston, MA 02114, USA. cfinn@partners.org

Current Psychiatry Reports
|March 29, 2001
PubMed
Summary

Genetic studies show panic disorder (PD) is familial, but identifying specific genes is challenging due to complexity. Research explores genetic epidemiology and novel strategies for PD etiology.

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Area of Science:

  • Psychiatry
  • Genetics
  • Epidemiology

Background:

  • Panic disorder (PD) is a significant anxiety disorder with a known familial aggregation.
  • Twin studies confirm a substantial genetic contribution to the familiality of PD.
  • The complexity of PD's phenotype presents challenges for genetic research.

Purpose of the Study:

  • To review the genetic epidemiology of panic disorder.
  • To summarize recent molecular genetic findings in PD.
  • To discuss strategies for identifying specific genetic loci contributing to PD etiology.

Main Methods:

  • Review of family and twin studies on PD.
  • Analysis of molecular genetic studies investigating PD risk genes.
  • Discussion of phenotypic definition challenges in genetic research.

Main Results:

  • Consistent evidence for familiality and heritability of PD.
  • Limited success in establishing specific genes or chromosomal regions for PD risk.
  • Ongoing debate regarding the inheritance of clinical PD versus underlying traits.

Conclusions:

  • Despite evidence of genetic influence, specific genes for PD remain elusive.
  • Clarifying the PD phenotype is crucial for advancing genetic studies.
  • Novel strategies are needed to uncover the genetic underpinnings of PD.

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